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Comparison between Intestinal Absorption of Some Drugs through the Rat Intestine and Ko/w of the Ionised Form of the Drugs For ionisable drugs where the ionised species does not partition into the aqueous phase, the apparent partition coefficient (D) can be calculated from following equations for acidic drugs , log D = log P - log [1 + 10(pH pKa)] (2.18) for basic drugs , log D = log P - log [1 + 10(pKa pH)] (2.19) The pH-partition hypothesis over-simplified the otherwise complicated process of drug absorption and therefore has its own limitations

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This is because both compounds affect gastrointestinal motility and appetite through their respective mechanisms, and layering them too aggressively creates compounding GI effects that can derail compliance

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