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From animal models to clinical trials: the promise of melatonin in cognitive health In animal models of AD, melatonin has shown promise in improving spatial memory and mitigating cognitive impairments

Gubbiotti MA, McCutcheon IE, Rao P, Genovese G, Wang L , Tarasov A, Putintsev V, Berlinski A, Stupichev D, Kriukov K, Davitavyan S, Salem B, Sarachakov A, Lebedev D, Hensley M, Bagaev A, Paradiso F, Kushnarev V, Khegai G, Tannir NM, Msaouel P

The major unsaturated fatty acids in RBO are oleic acid (38.4%), linoleic acid (34.4%), and -linolenic acid (2.2%), and the main saturated fatty acids are palmitate 54 (cetyl palmitate

NADPH oxidase was identified as the primary source of ROS, as the Rac1 subunit is translocated to the membrane to form an active NADPH oxidase complex