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Given that myelin itself is a lipid-rich structure, lipid metabolic disturbances occupy a central position in MS pathogenesis

Mechanical loading also affects skeletal muscle production by IGF-1, and low IGF-1 levels are associated with low handgrip strength and poor physical performance

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For example, the release of mitochondrial cytochrome c (Cyto-C) could initiate endogenous apoptosis with concomitant depolarization of the mitochondrial membrane potential (MMP) [24]