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Following injection, AdV particles target innate immune cells like DCs and macrophages and stimulate innate immune responses by engaging multiple pattern-recognition receptors including those that bind dsDNA in particular TLR9 to induce type I interferon secretion 8

Financially successful ACOs are likely to have already made significant investments in staffing and healthcare infrastructure, as they are necessary for the functioning of an ACO, and we stated that we intended to encourage ACOs receiving prepaid shared savings to invest in direct beneficiary services that are not already offered by the ACO