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found that dietary Gln supplementation can elevate Gln levels in the TME, decrease the expression of immunosuppressive genes such as Ctla4 and Nrp1 in Tregs, inhibit Treg differentiation, and consequently enhance the tumor immune response (52)

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SLE patients with diminished P2RY8 expression not only had a higher incidence of nephritis but also an increased number of age-associated B cells (ABCs), which are recognized as pathological in lupus nephritis and a significant source of autoantibody-producing cells [15]

This suggests that T cells expressing the disease associated TCRs have undergone clonal expansion in the inflamed tissues