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These may include acupuncture, chiropractic care, NeuroRehab, nutritional/ Functional Medicine counseling, and mindfulness practices such as meditation and breathwork

The amount of melatonin synthesized in peripheral cells is presumed to be cell specific and stress de-pendent, i.e., potentially upregulated in animal cells as has been well documented in plants ( Figure 2 )

A recent meta-analysis of clinical studies to identify and assess the various diagnostic tests indicated that a combination of intestinal permeability, Rome I criteria and fecal calprotectin (see Table 1) provided the highest positive likelihood ratio for predicting IBS (Sood et al., 2015)