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The FDA first approved exenatide, a synthetic version of GLP-1, in 2005, but Mounjaro is the first to feature a GIP mimic

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Unfortunately, this does not always make sense because there are conditions that also exist with cortisol levels that are in between zero cortisol and way too much

One of the major drawbacks is their large molecular mass of about 150 kDa, responsible for slow kinetics and limited tumor penetration with only approximately 20% of the administered dose reaching the tumor site [85]