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For individuals with digestive sensitivities, those taking acid-reflux medications, or anyone on a plant-based (vegan/vegetarian) diet, absorbing enough B12 through food or pills is virtually impossible

at a dose of 1.5 mg/kg 54

doi: 10.2174/1570159X20666220706121412 239 ShehataM

22 Interestingly, UV levels have also been shown to influence activity of the cSHMT enzyme, with a preliminary study observing translation of this enzyme as increased significantly in UV-exposed cells