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2.3.1 The relationship between ferroptosis and autophagy Appropriate autophagy has evolved into a pro-survival response for cells, but excessive autophagy, especially selective autophagy, and impaired lysosomal activity may promote cellular ferroptosis (92)

This activation is accompanied by vital methylation reactions that allow the synthesis of creatine and phosphatidylcholine and the methylation of DNA, RNA, and a large number of neuromediators

For example, CNS is very sensitive to H 2 S poisoning due to the minimal level of H 2 S catabolizing capacity

10.1139/apnm-2019-0359 [PubMed: 31697573] [CrossRef] Ahmad SY, Friel J, Mackay D (2020b)