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The expression of the aforementioned pro-inflammatory genes, which were highly upregulated by HFD, was substantially reduced in the HFD + Ret group

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2021;15:630502.[DOI] 140

The significant correlation between Kla-specific genes and lactate accumulation-related genes (e.g., P300, LDHA) reveals that Kla promotes BC progression and immune escape by affecting NK cell function and multiple signaling pathways (NOTCH, WNT, among others) (117)