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In lung cancer cells, GPX3 acts as an inhibitor of proliferation, migration and invasion of tumor cells by suppressing ROS-mediated NF-B signaling (27,39)

For instance, depletion of mGSH results in Trx2 oxidation (Zhang et al., 2007), while hypercholesterolemic pigs with selective depletion of mGSH in heart mitochondria, exhibit decreased levels of the mitochondria-specific antioxidant enzymes such as SOD2, Trx2, and Prx3 (McCommis et al., 2011)

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Biological activity of synthetic phosphonooxyethyl analogs of lipid A and lipid A partial structures