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Both endothelial cells and pericytes contribute to generate components of the basement membrane, which is a vital component of the BBB, providing structural support, cell anchoring, regulate immune cells, and signaling transduction [1, 29, 30]

Through the gutliver axis, microbiota-derived metabolites including butyrate may indirectly influence the hepatic microenvironment, potentially enhancing the efficacy of senolytic interventions by attenuating chronic inflammation and creating a metabolic state less permissive to cellular senescence 101

Sleep problems and suicide risk in youth: A systematic review, developmental framework, and implications for hospital treatment

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