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However, VEGF blockade alone is often accompanied by compensatory upregulation of Ang-2

Mitochondrial function: NAD+ supports mitochondrial health and biogenesis while glutathione protects mitochondrial membranes from peroxidation damage, ensuring adequate energy supply for cellular repair processes

Additionally, some patients with PCOS undergo ovulation induction treatments such as assisted reproductive technology (ART), leading to an increased incidence of twin or multiple pregnancies, which may further elevate the risk of pregnancy-induced hypertension (Neven et al., 2022