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These results show that although the expected therapeutic effect has not been achieved, AVV-based therapy has acceptable safety

The main difference is the pattern

339,340,341,342,343 Age-related mitochondrial decline further amplifies these defects, positioning mitochondrial deterioration as both a cause and consequence of neurodegeneration

Superoxides can first be degraded into H 2 O 2 by SOD, and subsequently, catalyzed into ground-state oxygen and water by catalase and enzymes of the glutathione redox cycle, including glutathione reductase and glutathione peroxidase