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Q: Is AOD-9604 intended for human or animal use

The engagement of the PD-1 receptor with PD-L1 activates PD-1 downstream from Src homology region 2 domain-containing protein tyrosine phosphatase (SHP-2) and dephosphorylates ZAP70, leading to the inhibition of T cell survival, proliferation and cytokine production, inducing T-cell exhaustion

Lab tests show the compound can enhance mitochondrial function through pathways similar to exercise, making it useful for researchers studying cellular adaptation mechanisms