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A systematic literature search was performed across PubMed/MEDLINE, Embase and the Cochrane Library using the following search terms, applied individually and in combination: BPC-157, Body Protection Compound 157, pentadecapeptide, GHK-Cu, glycyl-L-histydyl-L-lysine, copper peptide, wound healing, tissue repair, tendon healing, collagen synthesis, angiogenesis, regenerative medicine and sport medicine

The two peptides activate different receptors on pituitary somatotroph cells: the CJC-1295 acts via the GHRH-R and theIpamorelin via GHS-R1a

Decorin upregulation represents a fourth mechanism: decorin is a proteoglycan that organizes collagen fibril assembly and suppresses TGF-beta-mediated fibrosis, so its upregulation by GHK-Cu may support organized tissue repair with reduced scar formation