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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine

This phenomenon may occur in the lymphocytes during the development of an immune response or in muscular cells during strenuous exercise

If a patient is suspected to be experiencing OIH, carefully consider appropriately decreasing the dose of the current opioid analgesic, or opioid rotation (safely switching the patient to a different opioid moiety) (see DOSAGE AND ADMINISTRATION, WARNINGS)