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The deleterious effects such as a reduction of force generation and increased muscle atrophy appear to occur particularly after non-regular strenuous exercise, while regular training has positive effects by influencing cellular processes that lead to increased expression of antioxidants

Herring, J

Oncol Lett (2020) 20:374

10 Canonical NF-B pathway Components of canonical NF-B pathway NF-B family The precursor molecule p105 undergoes ubiquitination upon induction by the ubiquitin ligase Kip1 ubiquitination-promoting complex subunit 1 (KPC1), followed by proteasomal disassembly into the active form p50, and the nuclear localization sequence (NLS) masked by the remote structural domain of the p110 precursor is exposed, allowing cytoplasmic/nuclear signaling to proceed