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However, this marked decrease in endogenous peripheral ghrelin levels did not prevent the GHSR antagonists JMV2959 and PF-5190457 from reducing binge-like alcohol drinking

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Repetitive administration of GHRH has been shown to restore the attenuated response in different clinical trials (Table 1)

Jger R, Mohr AE, Carpenter KC, Kerksick CM, Purpura M, Moussa A, Townsend JR, Lamprecht M, West NP, Black K, Gleeson M, Pyne DB, Wells SD, Arent SM, Smith-Ryan AE, Kreider RB, Campbell BI, Bannock L, Scheiman J, Wissent CJ, Pane M, Kalman DS, Pugh JN, Ter Haar JA, Antonio J