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Through ADP-ribosylation of the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase by polyADP-ribose polymerase, ROS and advanced glycation end product (AGEs) production will rise (Figure 8) (Eelen et al., Figure 8 Furthermore, it has been hypothesized that glycogen stores in ECs are used as a backup source of energy when ECs migrate to regions with low glucose concentration (Bierhansl et al., 2016)

Its progression is closely linked to the activity and stability of GPX4, making the inhibition of lipid peroxidation and the preservation of GPX4 function pivotal targets in ferroptosis-based therapeutic interventions

It is well established that the chemical environment of the substantia nigra in PD is indicative of oxidative damage 11

However, you would have to empirically optimize the amount of beads to be used per volume of reaction