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However, the result of confocal imaging showed that the majority of the administered stapled peptide remains trapped in the lysosomal trafficking pathways, despite the NLS sequence promoting cellular uptake to a certain degree, indicating that endosomal escape continues to be the primary limiting factor affecting proper targeting and the technology of stapled peptides subcellular delivery remain further developed

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J Gerontol A Biol Sci Med Sci 75:20562063 Vetter VM, Sommerer Y, Kalies CH, Spira D, Bertram L, Demuth I (2022) Vitamin D supplementation is associated with slower epigenetic aging

Fun fact: Unlike most microbes, Sphingomonas can survive the wine fermentation process, making it a tiny microbial marker of a wine's unique "terroir", or the environments fingerprint on the wine