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Digestion-gut-autism connection: The specific carbohydrate diet

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The -glutamyl amino acid can be transported back into the cell where -glutamyl cyclo-transferase (GCT) releases the acceptor amino acid to form 5-oxo-proline, the latter of which is converted back to glutamate by oxo-prolinase and used for GSH synthesis

For example, ziziphi spinosae decoction ( Ligusticum chuanxiong hort , Glycyrrhiza glabra L , Semen ziziphi spinosae , Anemarrhena asphodeloides Bunge ) decreased has been reported to decrease the expression of glu and NMDAR1 (Lu et al., 2020)