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Int Arch Allergy Immunol 175(4):220230 Li W, Deng R, Jing X, Chen J, Yang D, Shen J (2020) Acteoside ameliorates experimental autoimmune encephalomyelitis through inhibiting peroxynitrite-mediated mitophagy activation

Although preclinical studies in colon cancer models show that IDO1 inhibition can enhance T cell infiltration when combined with antiCTLA-4 therapy (125, 126), clinical trials of IDO1 monotherapy have demonstrated limited efficacy (127), reflecting tumor-specific metabolic adaptations and compensatory mechanisms