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, I, J, K and M), the signals observed for thiomethyl metabolites were equivalent or higher than the ones observed for free APAP, indicating that a high proportion of reactive NAPQI was generated in these patients, and then reabsorbed into the systemic circulation before being eliminated

10.1007/s12010-024-05141-9 90 Malaekeh-NikoueiA.Shokri-NaeiS.KarbasforoushanS.BahariH.Baradaran RahimiV.HeidariR.et al (2023)

With its consistently strong binding affinity across all targets, particularly SIRT1, KEAP1, HO-1, and NQO1, PHL stands out as the most promising biocompound for modifying the Nrf2-mediated antioxidant defence system

M.ChuT.et al