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The aging process is marked by a persistent dysregulation between pro-oxidant and antioxidant mechanisms, resulting in the excessive production of ROS that hinder eNOS functionality, diminish NO bioavailability, and exacerbate endothelial dysfunction (19)

More patients in the Scrambler therapy group (60%) achieved a 50% or greater improvement in pain or tingling compared with TENS (25%), further suggesting Scrambler therapy may improve upon TENS therapy for CIPN symptom relief (Childs 2021)

High levels of choline, the source of TMAO, were associated with a 2.4-times greater incidence of the disease [29]

Stress, Cortisol, and Sleep Hygiene Stress is cited by patients as the number one trigger for outbreaks