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Rotroff DM, et al

Deficits in brain betaine levels may contribute to cellular osmotic perturbation (Knight et al., 2017

Pharmacological approaches aimed at disrupting mitochondrial metabolism, enhancing ROS accumulation, inhibiting mitochondrial antioxidant defenses, modulating mitochondrial dynamics, impairing mtDNA repair, and restoring mitochondrial-mediated apoptosis have demonstrated encouraging radiosensitizing effects in multiple preclinical and clinical studies (3436)