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Because their baseline cellular compartments are already highly saturated, administering standardized high doses yields diminished relative returns and increases the risk of sidetracking shared transport pathways for other essential cations

PLoS ONE 9(3):e87235

Berberine attenuates development of the hepatic gluconeogenesis and lipid metabolism disorder in type 2 diabetic mice and in palmitate-incubated HepG2 cells through suppression of the HNF-4 Mir122 pathway