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These systems achieve controlled drug release by modulating the physicochemical properties of polymers, such as solubility, release kinetics, and targeting capabilities, thereby enhancing therapeutic efficacy and reducing adverse effects ( 4.3.1 Basic polymeric nanocarrier systems Nanoparticle systems use polymeric nanoparticles as core carriers to effectively encapsulate drugs and deliver them to specific sites (e.g., joints and tumor regions) through passive or active targeting mechanisms (Zhao and Zhou, 2022)

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HER2 status was distributed as 0 in 56%, 1+ in 32%, 2+ in 6% and 3+ in 6%

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