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The following primary antibodies were used: anti-Sca-1 (Ly6a) (1:500, R&D Systems, #MAB1226), anti-Olfm4 (1:1000, Cell Signaling Technology, #39141), anti-Lysozyme (1:500, Dako, #A0099), anti-tdTomato (1:200, Origene, #AB8181), anti-Dclk1(1:100, Abgent, #AP7219B), anti-Chga(1:1000, Diasorin, #20085), anti-collagen I (1:200, Abcam, #ab270993) and anti-YAP(1:200, Cell signaling, #4912)

Research demonstrates that copper ions can inhibit up to 90% of type 1 5-alpha reductase at specific concentrations

There is a small amount of SOD3 that is found in plasma and extracellular fluids