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The absence of answers to these questions precludes the establishment of a direct causal relationship between NF1 and YAP1 ubiquitination

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Immune system: Friend and foe The immune system is central in the cachectic process as it links tumor masses and all tissues and organs directly implicated in the progression of cachexia, such as adipose tissue, brain, liver, gut, or heart

Since Nrf2 upregulates the expression of many antioxidant genes altering the activity of this transcription factor would affect a wide variety of antioxidant systems, which may represent a stronger approach than targeting only one antioxidant enzyme (reviewed in (Hybertson et al