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Future studies will reveal the applicability of our model, for example, to activate enzymatically inactive glutaredoxins, to alter the sensitivity and responsiveness of glutaredoxin-coupled fluorescent redox sensors, to further address the catalytic mechanism with GSSCys, HEDS and physiological substrates, or to design specific transition-state inhibitors

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doi: 10.3389/fphar.2025.1578472 Received 17 February 2025 Accepted 19 May 2025 Published 10 July 2025 Volume 16 - 2025 Edited by Michael Heinrich, University College London, United Kingdom Reviewed by Stefania Schiavone, University of Foggia, Italy Junbo Gou, Hubei University of Chinese Medicine, China Jie Guo, Jishou University, China Updates Copyright 2025 Kou, Meng, Zhao, Wang, Lu, Yan and Li

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