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Research has found associations between these genes and analgesic needs in both acute and chronic pain conditions, as well as pain sensitivity (Table 1).25,155159 The Genetic Addiction Risk Score (GARS) can help predict patient responses to opioids, facilitating personalized opioid analgesic therapy (Figure 7).155 Candidate genes, such as catechol-O-methyl-transferase and MORs, have been linked to analgesic requirements and pain sensitivity.158160 The GARS test measures risk polymorphisms across 10 reward genes (Figure 8)

Nature Aging 2021;1, 1117-1126, doi:10.1038/s43587-021-00151-2

Alpha-synuclein in Parkinsons disease and other synucleinopathies: From overt neurodegeneration back to early synaptic dysfunction

In addition, the authors would like to express their sincere gratitude to the Medical Experimental Center of the School of Basic Medicine and Public Health, Jinan University, for providing some of the experimental equipment for this study