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In another embodiment, the assay is a cell-based assay comprising contacting a cancer cell with a cytotoxic T cell, monocyte and/or macrophage and a test agent, and determining the ability of the test agent to modulate the copy number, amount and/or activity of at least one target listed in table 1 and/or table 2 and/or modulate an immune response, e.g., by measuring direct or indirect parameters as described below

Briefly, there are four possible mechanisms of CRPC development: 1) Increased sensitivity of the AR to its agonists, 2) AR mutations that render the receptor responsive to alternate, non-androgen ligands, 3) ligand-independent AR activation, and 4) AR-independent mechanisms (Figure 5)

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In the SURPASS clinical trial program for type 2 diabetes, patients achieved HbA1c reductions of 1.9% to 2.6% depending on dose, with weight loss averaging 15-22 pounds across studies