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The mechanism of action involves activation of both GIP and GLP-1 receptors, which are expressed throughout the body including the pancreas, gastrointestinal tract, and central nervous system

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Int J Biochem Cell Biol 37:19741984 van Royen M, Carb N, Busquets S, Alvarez B, Quinn LS, Lpez-Soriano FJ, Argils JM (2000) DNA fragmentation occurs in skeletal muscle during tumor growth: a link with cancer cachexia