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Furthermore, an excessive lack of Trp will result in an increase in Kyn synthesis during Trp metabolism, preventing effector T cells and natural killer cells from proliferating and functioning

26 Chronic alcohol consumption disrupts the gut barrier, leading to increased gut permeability, and ectopic immune stimulation

doi: 10.1111/cns.14368 82 HumeDARossILHimesSRSasmonoRTWellsCARavasiT

For example, kudzu resistant starch improves the gut barrier, inhibits the LPS/Toll-like receptor 4 (TLR4)/NF-B inflammatory pathway, and alleviates hepatic steatosis by increasing the abundance of butyrate-producing bacteria (such as Coprococcus and Bifidobacterium ) and elevating plasma butyrate levels