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In addition, using an anti-HPV-16 E7 antibody we immunoprecipitated HPV-16 E7 in the CaSki [20] and SiHa [21] cervical carcinoma cell lines, known to express HPV-16 E7 endogenously [22], [23], GSTP1 also co-precipitated with the viral oncoprotein in these cells, as detected by Western blot analysis (Figure 1F)

Consequently, these imbalances lead to more significant changes and consequences compared to those usually observed in humans or domestic animals

In addition, lipid metabolism further acts as a critical regulatory node within complicated network