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Clinical manifestation MDMA Toxicokinetic: Half-life is 5-10 hours Increases the chances of dehydration, hypertension, heart or kidney failure, and increased body temperature, which can lead to death

PTEN PTEN loss in GBM drives tumor progression and therapeutic resistance by dysregulating the PI3K/AKT/mTOR pathway, leading to uncontrolled cell growth, immune evasion, and an immunosuppressive TME