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But hyperuricemia develops in two ways: Your body makes too much uric acid Your kidneys can't get rid of enough uric acid [1] Your uric acid levels can rise because of: Diet : Foods packed with purines (red meat, organ meats, seafood), alcoholic drinks (especially beer), and fructose-sweetened drinks [1] Weight : Extra pounds make more uric acid and make it harder for kidneys to work [1] Medical conditions : High blood pressure, diabetes, metabolic syndrome, heart and kidney diseases that aren't treated [1] Medications : Diuretics, low-dose aspirin, beta-blockers, and immunosuppressants [1] Genetics : Your family's history plays a big role in your risk [1] Everything in hyperuricemia is needed to get goutbut only 22% of men with uric acid levels above 9.0 mg/dL get gout within five years [1]

Assessment of endothelial dysfunction: The determination of endothelial dysfunction was performed according to the method described by Celemajer et al

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doi: 10.1016/s1369-5266(03)00039-6