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Despite the relatively short half-life, clinical effects can persist for several hours to days after administration, suggesting that pharmacodynamic effects outlast plasma drug levels through persistent changes in neural circuit activity initiated by melanocortin receptor activation

Nevertheless, it can be hypothesized, that the whole PBMC population was experiencing metabolic stress by LPS addition in the present study, which may be the reason for decreased OCR

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Furthermore, it is crucial to understand that skin lightening is not a one-size-fits-all solution and that natural skin color variations should be celebrated rather than stigmatized