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Isidore was tortured by the Romans, he was left bleeding under a mastic tree

This type of binding is followed by receptor- mediated internalization, also in a vesicle

References Aal-Aaboda M et al (2022) Lipopolysaccharide from Rhodobacter spheroids modulate toll-like receptors expression and tissue damage in an animal model of bilateral renal ischemic reperfusion injury

These challenges arise not only from methodological heterogeneity but also from biological complexity, and they must be addressed to enable translation of mechanistic findings into clinical application