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In some rare cases, this has resulted in fingers, toes or arms, needing to be amputated, he said

In addition, inflammation and the pathophysiology of DN involve complex signaling pathway activation (Bui et al., 2020), such as NF-B pathway, The janus kinase/signal transducers and activators of transcription (JAKSTAT) pathway and nod-like receptor (NLR) family pyrin domain containing 3 (NLRP3) inflammasome pathway

Cellular defence mechanisms against free radicals include control imposed by membrane structure, neutralization by glutathione, control exerted by non-enzymatic antioxidant scavengers such as vitamins A, E and C and enzymatic inactivation of oxygen derived free radicals

Zhang, Avni P