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What they found: No serious adverse events triggered by AOD-9604 The most frequent side effects: headache (~5 %), occasional fatigue, at the same frequency as placebo No changes in IGF-1 levels, glycemia, blood pressure, heart rate No signals of cardiovascular, hepatic or renal toxicity Safety profile comparable to placebo Why it matters: From a safety perspective, AOD-9604 is one of the safest peptides in the clinical registry

An amido group refers to an CONH 2 group

Individuals with bone marrow disorders 10 , 11

Because the degree of resolution of the clinical symptoms in B 12 deficiency depends on early detection, MR findings should not be overlooked