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Direct inhibition of sympathetic nerve function by reducing the biosynthesis of NE, preventing the conversion of DA to NE in sympathetic nerves, and possibly by increasing the release of DA, can induce renal vasodilation, diuresis, and natriuresis

The same body of research also found that higher doses of GHK-Cu can produce skin irritation, and that copper in general is highly toxic, which is why formulation and concentration matter considerably in any experimental design involving this compound

Copper peptides can be used by people with sensitive skin, but the risk of reaction is higher and the reintroduction needs to be slower

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