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70 As cells use NADPH to reduce cystine to cysteine, the increased cysteine catabolism by CDO implies the increased consumption of NADPH, which will affect other cell metabolic pathways and the antioxidant capacity as well

The cytoprotective role of the Keap1-Nrf2 pathway

Metabolomic alterations in the blood plasma of older adults with mild cognitive impairment and Alzheimer's disease (from the Nakayama Study)

Genetic and metabolic studies have further shown that metabolites such as succinate and fumarate, which are generated under normal physiological conditions, are associated with tumorigenesis in several cancer types