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Vascular aging is a root cause of cardiovascular disease, the leading cause of death globally

In a chronic social defeat stress model in mice, 21 days of oral administration at 0.1 mg/kg corrected depressive-like behavior, restored motor activity with a therapeutic effect of 60 percent, completely recovered anhedonia, restored synaptophysin levels (74 percent therapeutic effect), and fully restored CREB levels in the hippocampus

In previous work, Tsais lab has shown that transgenic mice engineered to express P25 develop severe neurodegeneration

doi: 10.3390/ijms25179302 167 Committee on Carcinogenicity of Chemicals in Food, Consumer Products and the Environment (COC)