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Description

J Physiol Pharmacol 2005

Mitochondrial dysfunction contributes to rapamycin-induced apoptosis of human glioblastoma cells - a synergistic effect with Temozolomide

Using two different cell lines and a xenograft mouse model of CRC, it was shown that 2-Imino-6-methoxy-2H-chromene-3-carbothioamide (IMCA), a benzopyran derivative, downregulates SLC7A11 levels leading to increased ROS and ferroptosis in CRC cells