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1) were assessed by pathway enrichment in MetaboAnalyst 6.0 using the Small Molecule Pathway Database (SMPDB) with 99 metabolite sets from normal human metabolic pathways and was enriched for Methionine Metabolism, Phenylacetate Metabolism, Pantothenate and CoA Biosynthesis, Pyrimidine Metabolism, Glycine and Serine Metabolism, Arginine and Proline Metabolism, Riboflavin Metabolism and Betaine Metabolism (Fig

Tretinoin binds to all three RARs but does not bind to RXRs except at very high concentrations

Another study also demonstrated that anxiety, depression and cognitive impairments induced by psychosocial stress are ameliorated by quercetin and also by modulating plasma corticosterone and adrenocorticotropic hormone levels, as well as corticotropin-releasing factor (CRF) mRNA expression in the hypothalamic region [183]

This comparable activity may be attributed to the similar total phenolic content present in both extracts