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Tumor cell-intrinsic mechanisms underlying such phenotype remain poorly understood and were the subject of this study

However, there is an impressive body of evidence indicating that AD is a systemic metabolic disease (Perry et al., 2003), and it has originated as a vascular disorder with the resultant impairment of the delivery and transport of essential nutrients, particularly glucose and oxygen resulting in an energy metabolic breakdown with the plaques and tangles found in the brain secondary to the effects of the vascular pathology (de la Torre, 2002a)

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