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Metabolic reprogramming is a defining characteristic of cancer cells, which undergo metabolic alterations to maintain tumorigenicity and survive in the presence of immune cells and chemotherapy agents 4

20 Several other studies have confirmed an association between a blunted CAR and stress-related disorders, such as burnout, PTSD, cognitive deficits, and chronic fatigue syndrome

Thus, luteolins mechanisms of action on fibroblasts include inhibition of NF-B activation, which is crucial for inflammatory responses [244], and modulating MAPK and PI3K/Akt pathways to regulate cell adhesion and inflammation [245] and suppressing TGF-1 signaling, which is central to fibroblast-to-myofibroblast differentiation and the progression of fibrosis [19]

Toxins accumulate, oxidative damage accelerates, and recovery slows down