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These were all 5-HT1b agonists characterized for their ability to inhibit food consumption, but also had effects on other serotonin receptors that lead to unacceptable side effects (cardiac valvular thickening) and were voluntarily withdrawn from the market

[DOI] [PubMed] [Google Scholar] 72.Pillai, S

Reacting to our concerns about the alternative oral treatment the new guideline states clearly that if patients experience any neurological symptoms numbness or pins and needles then he or she must contact their GP immediately